Anti-Prostaglandin D Synthase (hematopoietic-type, mouse) Antiserum

Anti-Prostaglandin D Synthase (hematopoietic-type, mouse) Antiserum
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10004348-1 1 each -

6 - 10 business days*

324.00€
 
Prostaglandin D synthase (PGDS) is a glutathione-dependent enzyme and member of the sigma class... more
Product information "Anti-Prostaglandin D Synthase (hematopoietic-type, mouse) Antiserum"
Prostaglandin D synthase (PGDS) is a glutathione-dependent enzyme and member of the sigma class of glutathione-S-transferases (GSTs) that catalyzes the conversion of PGH2 (Cay-17020) to PGD2 (Cay-12010), an eicosanoid that has numerous biological functions, including vasorelaxation, recruitment of inflammatory cells, and inhibition of platelet aggregation. There are two types of PGDS: lipocalin PGDS (L-PGDS, Cay-10006788, Cay-10006787, Cay-10010548) and hematopoietic PGDS (H-PGDS, Cay-10006593, Cay-10004347). H-PDGS is found in peripheral tissues and immune cells, including Th2 cells, antigen-presenting cells, mast cells, megakaryocytes, and eosinophils, where it is localized to the cytosol. H-PGDS activity is increased by a variety of stimuli, including LPS, anti-IgE antibodies, phorbol 12-myristate 13-acetate (TPA, Cay-10008014), ionomycin (Cay-10004974), and inflammatory cytokines such as IL-13, IL-3, or IL-4. siRNA silencing of Hpgds decreases LPS-induced production of PGD2 in mouse bone marrow-derived macrophages (BMDMs). Transgenic overexpression of HPGDS in mice increases croton oil-induced ear swelling and PGD2 production, and genome-wide deletion of Hpgds exacerbates hypotension and vascular permeability in a mouse model of anaphylaxis. H-PGDS protein levels are increased in the nasal mucosa of patients with allergic rhinitis, and HPGDS SNPs have been found in individuals with asthma. Cayman's Prostaglandin D Synthase (hematopoietic-type, mouse) Polyclonal Antiserum can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes H-PGDS at 23 kDa from human and mouse samples. Synonyms: H-PGD Synthase, H-PGDS. Immunogen: Recombinant mouse H-PGDS. MW: 23 kDa. Formulation: 200 µl polyclonal antiserum with 0.02% sodium azide. Storage Buffer: Lyophilized from serum, resuspend 200 µl double distilled water. Host: Rabbit. Applications: IHC, WB. UniProt Accession #: Q9JHF7.
Keywords: Anti-Gsts, Anti-H-PGDS, Anti-H-PGDS, Anti-GST class-sigma, Anti-GST class-sigma, Anti-Glutathione S-transferase, Anti-Glutathione S-transferase, Anti-Prostaglandin-H2 D-isomerase, Anti-Prostaglandin-H2 D-isomerase, Anti-Glutathione-dependent PGD synthase,
Supplier: Cayman Chemical
Supplier-Nr: 10004348

Properties

Application: IHC, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Mouse
Immunogen: Recombinant mouse H-PGDS
Format: Lyophilized

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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