Anti-Prostaglandin D Synthase (hematopoietic-type, human)

Anti-Prostaglandin D Synthase (hematopoietic-type, human)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10004337-1 1 each -

6 - 10 business days*

422.00€
 
Prostaglandin D synthase (PGDS) is a glutathione-dependent enzyme and member of the sigma class... more
Product information "Anti-Prostaglandin D Synthase (hematopoietic-type, human)"
Prostaglandin D synthase (PGDS) is a glutathione-dependent enzyme and member of the sigma class of glutathione-S-transferases (GSTs) that catalyzes the conversion of PGH2 (Cay-17020) to PGD2 (Cay-12010), an eicosanoid that has numerous biological functions, including vasorelaxation, recruitment of inflammatory cells, and inhibition of platelet aggregation. There are two types of PGDS: lipocalin PGDS (L-PGDS, Cay-10006788, Cay-10006787) and hematopoietic PGDS (H-PGDS, Cay-10006593). H-PGDS is found in peripheral tissues and immune cells, including Th2 cells, antigen-presenting cells, mast cells, megakaryocytes, and eosinophils, where it is localized to the cytosol. H-PGDS activity is increased by a variety of stimuli, including LPS, anti-IgE antibodies, phorbol 12-myristate 13-acetate (TPA, Cay-10008014), ionomycin (Cay-10004974), and inflammatory cytokines such as IL-13, IL-3, or IL-4. siRNA silencing of Hpgds decreases LPS-induced production of PGD2 in mouse bone marrow-derived macrophages (BMDMs). Transgenic overexpression of HPGDS in mice increases croton oil-induced ear swelling and PGD2 production, and genome-wide deletion of Hpgds exacerbates hypotension and vascular permeability in a mouse model of anaphylaxis. H-PGDS protein levels are increased in the nasal mucosa of patients with allergic rhinitis, and HPGDS SNPs have been found in individuals with asthma. Cayman's Prostaglandin D Synthase (hematopoietic-type, human) Polyclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes H-PGDS at ~24 kDa from human and mouse samples.Synonyms: H-PGD Synthase, H-PGDS, Hematopoietic-PGDS, hH-PGDS, PGD Synthase (hematopoietic-type). Immunogen: Recombinant human H-PGD. MW: ~24 kDa. Formulation: (Request formulation change), Protein A-purified polyclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Rabbit. Applications: IHC and WB. Cross Reactivity: (+) H-PGDS. UniProt Accession #: O60760. Origin: Animal/Rabbit.
Keywords: Anti-GSTS, Anti-H-PGDS, Anti-H-PGDS, Anti-GST class-sigma, Anti-GST class-sigma, Anti-Glutathione S-transferase, Anti-Glutathione S-transferase, Anti-Prostaglandin-H2 D-isomerase, Anti-Prostaglandin-H2 D-isomerase, Anti-Glutathione-dependent PGD synthase,
Supplier: Cayman Chemical
Supplier-Nr: 10004337

Properties

Application: WB, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Immunogen: Recombinant human H-PGD synthase
Format: Lyophilized

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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