Anti-PRDM2 (PRDM2, KMT8, RIZ, PR domain zinc finger protein 2, GATA-3-binding protein G3B, Lysine N-

PRDM2 is a 250-kD nuclear protein containing 8 zinc finger motifs. It contains an RB-binding motif that is related to that of the adenovirus E1A oncoprotein, RIZ also shares an antigenic epitope with the C terminus of E1A. It is expressed in human retinoblastoma cells and at low levels in all other human cell lines examined. Using fluorescence in situ hybridization, the PRDM2 gene has been mapped to 1p36. PRDM2 may be a candidate target of 1p36 alterations that commonly occur in neuroendocrine, breast, liver, colon, skin, and lymphoid tumors. Applications: Suitable for use in Western Blot, Immunohistochemistry, Immunoprecipitation, FLISA, Recommended Dilution: FLISA: 1:1,000, Western Blot1:100-500, Immunohistochemistry: 1:100-500, Immunoprecipitation: 1 ug Pab/100 ug cell lysate, Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap., , Note: Applications are based on unconjugated antibody.