Anti-PPP4C

Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-60612.60 60 µl -

7 - 16 business days*

198.00€
E-AB-60612.120 120 µl -

7 - 16 business days*

317.00€
E-AB-60612.200 200 µl -

7 - 16 business days*

525.00€
 
Protein function: Protein phosphatase that is involved in many processes such as microtubule... more
Product information "Anti-PPP4C"
Protein function: Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase. In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin. [The UniProt Consortium]
Keywords: Anti-Pp4, Anti-PP4C, Anti-PP-X, Anti-PPP4, Anti-PPP4C, Anti-Protein phosphatase X, Anti-Serine/threonine-protein phosphatase 4 catalytic subunit, PPP4C Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-60612

Properties

Application: WB, IHC, IF, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: Recombinant protein of human PPP4C

Handling & Safety

Storage: -20°C
Shipping: 4°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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