Anti-PPM1D, ID (PPM1D, WIP1, Protein phosphatase 1D, Protein phosphatase 2C isoform delta, Protein p

Anti-PPM1D, ID (PPM1D, WIP1, Protein phosphatase 1D, Protein phosphatase 2C isoform delta, Protein p
Item number Size Datasheet Manual SDS Delivery time Quantity Price
040324.200 200 µl - -

1 - 19 business days

557.00€
 
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases.... more
Product information "Anti-PPM1D, ID (PPM1D, WIP1, Protein phosphatase 1D, Protein phosphatase 2C isoform delta, Protein p"
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. Applications: Suitable for use in Western Blot and ELISA. Other applications have not been tested. Recommended Dilution: Western Blot: 1:1000, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-WIP1, Anti-PPM1D, Anti-PP2C-delta, EC=3.1.3.16, Anti-Protein phosphatase 1D, Anti-p53-induced protein phosphatase 1, Anti-Protein phosphatase 2C isoform delta, Anti-Protein phosphatase magnesium-dependent 1 delta
Supplier: United States Biological
Supplier-Nr: 040324

Properties

Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: PPM1D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 182-212 amino acids from the Central region of human PPM1D.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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