Anti-PMAIP1 (Phorbol-12-Myristate-13-Acetate Induced Protein 1, APR, NOXA)

Anti-PMAIP1 (Phorbol-12-Myristate-13-Acetate Induced Protein 1, APR, NOXA)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
P4285-50C.50 50 µg - -

4 - 22 business days

650.00€
 
Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces... more
Product information "Anti-PMAIP1 (Phorbol-12-Myristate-13-Acetate Induced Protein 1, APR, NOXA)"
Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA. A new p53 target gene, Noxa, was recently identified (1), which encodes a protein belonging to the subfamily of BH3-only proapoptic proteins. Noxa and PUMA are both transcriptional targets of p53 and BH3-only proteins. X-ray irradiation increased p53-dependent Noxa mRNA and protein levels. Noxa, when ectopically expressed, interacted with anti-apoptotic Bcl-2 family members, resulting in the activation of caspase-9 (1). Noxa, like PUMA, localized to mitochondria and induces apoptosis in response to p53 (1-3). Noxa and PUMA may represent direct mediators of p53-induced apoptosis. Increased levels of p53 and its target gene Noxa was found in the impaired tumor development (4). Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications have not been tested. Recommended Dilutions: Immunohistochemistry: 10ug/ml, Western Blot: 1-2ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: Anti-Protein Noxa, Anti-PMA-induced protein 1, Anti-Immediate-early-response protein APR, Anti-Phorbol-12-myristate-13-acetate-induced protein 1
Supplier: United States Biological
Supplier-Nr: P4285-50C

Properties

Application: IHC, WB
Antibody Type: Polyclonal
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, KLH-conjugated. Epitope: A mixture of synthetic peptides containing amino acids 51-66 and 75-90 of mouse Noxa.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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