Anti-PKN2

Anti-PKN2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-443A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A302-443A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A302-443A 100 µl (20 µg) -

3 - 9 business days*

465.00€
 
Protein function: PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that... more
Product information "Anti-PKN2"
Protein function: PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c- fos serum response factor (SRF). Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. [The UniProt Consortium]
Keywords: Anti-PKN2, Anti-PRK2, Anti-PKN gamma, EC=2.7.11.13, Anti-Protein kinase C-like 2, Anti-Protein-kinase C-related kinase 2, Anti-Serine/threonine-protein kinase N2
Supplier: Bethyl Laboratories
Supplier-Nr: A302-443A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Mouse, Rat)
Immunogen: synthetic peptide. The epitope recognized by A302-443A-T maps to a region between residue 200 and 250 of human protein kinase N2 using the numbering given in entry NP_006247.1 (GeneID 5586).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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