Anti-PIN1, clone 855CT1.7.5

Anti-PIN1, clone 855CT1.7.5
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-F52353-0.08ML 80 µl - -

3 - 10 business days*

326.00€
NSJ-F52353-0.4ML 400 µl - -

3 - 10 business days*

702.00€
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. Essential PPIase that regulates mitosis presumably by... more
Product information "Anti-PIN1, clone 855CT1.7.5"
In 1X PBS, pH 7.4, with 0.09% sodium azide. Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. Protein function: Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr- Pro) motifs in a subset of proteins, resulting in conformational changes in the proteins (PubMed:21497122, PubMed:22033920). Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923). [The UniProt Consortium]
Keywords: Anti-PIN1, EC=5.2.1.8, Anti-PPIase Pin1, Anti-Rotamase Pin1, Anti-Peptidyl-prolyl cis-trans isomerase Pin1, Anti-Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, PIN1 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: F52353

Properties

Application: IHC, WB, ELISA
Antibody Type: Monoclonal
Clone: 855CT1.7.5
Conjugate: No
Host: Mouse
Species reactivity: human, mouse, rat
Immunogen: Purified His-tagged protein was used to produced this monoclonal PIN1 antibody.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-PIN1, clone 855CT1.7.5"
Write a review
or to review a product.
Viewed