Anti-PI3K (p85 beta) / PIK3R2

Anti-PI3K (p85 beta) / PIK3R2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-R31788 100 µg - -

3 - 10 business days*

755.00€
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. PIK3R2 (Phosphatidylinositol 3-kinase,... more
Product information "Anti-PI3K (p85 beta) / PIK3R2"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. PIK3R2 (Phosphatidylinositol 3-kinase, regulatory subunit 2), also called p85-Beta, is an enzyme that in humans is encoded by the PIK3R2 gene. The PIK3R2 gene is mapped on 19p13.11. Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. Protein function: Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5- trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin- dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement. [The UniProt Consortium]
Keywords: Anti-PIK3R2, Anti-PI3-kinase subunit p85-beta, Anti-PI3K regulatory subunit beta, Anti-PI3-kinase regulatory subunit beta, Anti-PtdIns-3-kinase regulatory subunit beta, Anti-PtdIns-3-kinase regulatory subunit p85-beta, PI3K Antibody (p85 beta) / PIK3R2
Supplier: NSJ Bioreagents
Supplier-Nr: R31788

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: Amino acids KYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQL of human PIK3R2 were used as the immunogen for the PIK3R2 antibody.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-PI3K (p85 beta) / PIK3R2"
Write a review
or to review a product.
Viewed