Anti-PI3 Kinase p85 alpha

Item number Size Datasheet Manual SDS Delivery time Quantity Price
ARG40239.100 100 µl - -

6 - 14 business days

483.00€
 
Protein function: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2... more
Product information "Anti-PI3 Kinase p85 alpha"
Protein function: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923). [The UniProt Consortium]
Keywords: Anti-GRB1, Anti-PIK3R1, Anti-PI3-kinase subunit p85-alpha, Anti-PI3K regulatory subunit alpha, Anti-PI3-kinase regulatory subunit alpha, Anti-PtdIns-3-kinase regulatory subunit alpha, Anti-PtdIns-3-kinase regulatory subunit p85-alpha
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG40239100

Properties

Application: FC, ICC, IF, IHC (paraffin), WB
Antibody Type: Monoclonal
Conjugate: No
Host: Mouse
Reactivity: Human, Mouse
Immunogen: Purified recombinant fragment corresponding to aa. 159-388 of Human PI3 Kinase p85 alpha
MW: 53.4 kD
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: °C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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