Anti-Phosphodiesterase 4B (PDE4B, PDEIVB, cAMP-specific 3',5'-cyclic Phosphodiesterase 4B, DPDE4, PD

Anti-Phosphodiesterase 4B (PDE4B, PDEIVB, cAMP-specific 3',5'-cyclic Phosphodiesterase 4B, DPDE4, PD
Item number Size Datasheet Manual SDS Delivery time Quantity Price
P4072-03S1.100 100 µg - -

3 - 19 business days*

675.00€
 
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide... more
Product information "Anti-Phosphodiesterase 4B (PDE4B, PDEIVB, cAMP-specific 3',5'-cyclic Phosphodiesterase 4B, DPDE4, PD"
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Applications: Suitable for use in ELISA and Western Blot. Other applications have not been tested. , Recommended Dilutions: Peptide ELISA Titer: 1:8000, Western Blot: 0.5-1ug/ml ~85kD band observed in Mouse Brain lysates (calculated MW of 83.3kD according to Human NP_002591.2 and 82.1kD according to Mouse NP_062814.2). In transfected HEK293 transiently expressing Human PDE4B a band of approx. 85kD is observed. This band is not observed in the non-transfected HEK293., Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: EC=3.1.4.17, Anti-cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Supplier: United States Biological
Supplier-Nr: P4072-03S1

Properties

Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Goat
Species reactivity: human, mouse
Immunogen: Synthetic peptide corresponding to C-DIDIATEDKSPVDT, from the C Terminus of human Phosphodiesterase 4B (NP_002591.2, NP_001032418.1, NP_001032416.1, NP_001032417.1).
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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