Anti-phospho-PPP1A (Thr320)

Anti-phospho-PPP1A (Thr320)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ARG58267.50 50 µl - -

6 - 14 business days*

520.00€
 
Protein function: Protein phosphatase that associates with over 200 regulatory proteins to form... more
Product information "Anti-phospho-PPP1A (Thr320)"
Protein function: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5- ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323). [The UniProt Consortium]
Keywords: Anti-phospho-PP-1A, Anti-phospho-PPP1A, Anti-phospho-PPP1CA, Anti-phospho-Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG58267

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse
Immunogen: Phospho specific peptide corresponding to residues surrounding Thr320 of Human PPP1A
MW: 38 kD
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: °C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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