Anti-PDZ-GEF1

Anti-PDZ-GEF1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A301-966A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A301-966A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A301-966A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: Functions as a guanine nucleotide exchange factor (GEF), which activates Rap... more
Product information "Anti-PDZ-GEF1"
Protein function: Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10608844, PubMed:10548487, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP- induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Provides also inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain- derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. [The UniProt Consortium]
Keywords: Anti-RAPGEF2, Anti-PDZ-GEF1, Anti-RA-GEF-1, Anti-CNrasGEF, Anti-nRap GEP, Anti-KIAA0313, Anti-Cyclic nucleotide ras GEF, Anti-Ras/Rap1-associating GEF-1, Anti-Rap guanine nucleotide exchange factor 2, Anti-Neural RAP guanine nucleotide exchange protein
Supplier: Bethyl Laboratories
Supplier-Nr: A301-966A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse (Expected: Dog)
Immunogen: synthetic peptide. The epitope recognized by A301-966A-T maps to a region between residue 975 and 1025 of human PDZ domain containing guanine nucleotide exchange factor (GEF) 1 using the numbering given in entry NP_055062.1 (GeneID 9693).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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