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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-F40239-0.08ML | 80 µl | - | - |
3 - 10 business days* |
326.00€
|
||
NSJ-F40239-0.4ML | 400 µl | - | - |
3 - 10 business days* |
702.00€
|
In 1X PBS, pH 7.4, with 0.09% sodium azide. Inhibits the mitochondrial pyruvate dehydrogenase... more
Product information "Anti-PDK2, clone 180CT10.2.3"
In 1X PBS, pH 7.4, with 0.09% sodium azide. Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism. Protein function: Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis. [The UniProt Consortium]
Keywords: | Anti-PDK2, Anti-PDKII, Anti-PDHK2, EC=2.7.11.2, Anti-PDH kinase 2, Anti-Pyruvate dehydrogenase kinase isoform 2, Anti-[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial, PDK2 Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | F40239 |
Properties
Application: | WB, ELISA |
Antibody Type: | Monoclonal |
Clone: | 180CT10.2.3 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human, mouse |
Immunogen: | This PDK2 antibody was produced from a mouse immunized with PDK2 recombinant protein. |
Format: | Purified |
Database Information
KEGG ID : | K00898 | Matching products |
UniProt ID : | Q15119 | Matching products |
Gene ID | GeneID 5164 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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