Anti-PDGFB

Anti-PDGFB
Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-40267.20 20 µl - -

7 - 16 business days*

55.00€
E-AB-40267.60 60 µl - -

7 - 16 business days*

109.00€
E-AB-40267.120 120 µl - -

7 - 16 business days*

200.00€
E-AB-40267.200 200 µl - -

7 - 16 business days*

328.00€
 
The protein encoded by this gene is a member of the platelet-derived growth factor family. The... more
Product information "Anti-PDGFB"
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Protein function: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA. [The UniProt Consortium]
Keywords: Anti-Pdgfb, Anti-PDGF-2, Anti-PDGF subunit B, Anti-Platelet-derived growth factor B chain, Anti-Platelet-derived growth factor subunit B, Anti-Platelet-derived growth factor beta polypeptide, PDGFB Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-40267

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Rat
Immunogen: Recombinant Rat Platelet-derived growth factor subunit B protein

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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