Anti-PDCD1 / PD1 / CD279 (Programmed Cell Death 1) Polyclonal Antibody

Anti-PDCD1 / PD1 / CD279 (Programmed Cell Death 1) Polyclonal Antibody
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABE-36-2907-20 20 µg -

3 - 11 business days*

287.00€
ABE-36-2907-100 100 µg -

3 - 11 business days*

661.00€
 
PDCD-1 (programmed cell death-1 protein), also designated CD279, is a type I transmembrane... more
Product information "Anti-PDCD1 / PD1 / CD279 (Programmed Cell Death 1) Polyclonal Antibody"
PDCD-1 (programmed cell death-1 protein), also designated CD279, is a type I transmembrane receptor and a member of the immunoglobin gene superfamily. It is expressed on activated T-cells, B-cells, and myeloid cells. Anti-PDCD-1 is a marker of angioimmunoblastic lymphoma and sµggests a unique cell of origin for this neoplasm. Unlike CD10 and BCL6, PDCD-1 is expressed by few B-cells, so anti-PDCD-1 may be a more specific and useful diagnostic marker in angioimmunoblastic lymphoma. In addition, PDCD-1 expression provides evidence that angioimmunoblastic lymphoma is a neoplasm derived from germinal center-associated T-cells. Protein function: Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self (PubMed:21276005). Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2 (PubMed:21276005). Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta. [The UniProt Consortium]
Keywords: Anti-CD279, Anti-hPD-1, Anti-Protein PD-1, Anti-Programmed cell death protein 1, Anti-PDCD1 / PD1 / CD279 (Programmed Cell Death 1) Polyclonal Antibody
Supplier: Abeomics
Supplier-Nr: 36-2907

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: Human recombinant PDCD1 protein fragment

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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