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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay32253-100 | 100 µl | - |
6 - 10 business days* |
525.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Programmed cell death protein 1 (PD-1), also known as CD279, is a cell surface receptor belonging... more
Product information "Anti-PD-1/CD279 (N-Term) Rabbit Monoclonal Antibody (Clone RM309)"
Programmed cell death protein 1 (PD-1), also known as CD279, is a cell surface receptor belonging to the immunoglobulin superfamily that is involved in regulation and attenuation of the adaptive immune response. It is a 288-amino acid type I transmembrane protein encoded by the PDCD1 gene in humans and is comprised of a 167-amino acid ectodomain consisting of an N-loop, IgV-like domain, and a stalk region, a transmembrane domain, and a cytoplasmic tail with two tyrosine-based signaling motifs. PD-1 is expressed in activated immune cells including CD4+ T cells, CD8+ T cells, natural killer T (NKT) cells, B cells, monocytes, and dendritic cells. Binding of PD-1 to either of its ligands, PD-L1 (Cay-28378) or PD-L2 (Cay-28379), suppresses T cell proliferation and cytokine production. PD-1 deficiency induces cardiomyopathy or lupus-like glomerulonephritis in BALB/c and C57Bl/6 mice, respectively. Increased levels of intratumoral PD-1+ immune cells are associated with increased tumor size, higher nuclear grade, and poor prognosis in patients with renal cell carcinoma. Formulations containing PD-1 blocking antibodies have been used in the treatment of various cancers. Cayman's PD-1/CD279 (N-Term) Rabbit Monoclonal Antibody (Clone RM309) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.Synonyms: CD279, PDCD1, Programmed Cell Death Protein 1. Immunogen: Peptide from the N-terminal region of human PD-1. Clone Designation: RM309. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody.. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: IHC, WB. Cross Reactivity: (+) PD-1.
Keywords: | CD279, PDCD1, Programmed Cell Death Protein 1 |
Supplier: | Cayman Chemical |
Supplier-Nr: | 32253 |
Properties
Application: | IHC, WB |
Antibody Type: | Monoclonal |
Clone: | RM309 |
Conjugate: | No |
Host: | Rabbit |
Immunogen: | Peptide from the N-terminal region of human PD-1 |
Format: | Purified |
Database Information
KEGG ID : | K06744 | Matching products |
UniProt ID : | Q15116 | Matching products |
Gene ID | GeneID 5133 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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