Anti-PD-1/CD279 (N-Term) Rabbit Monoclonal Antibody (Clone RM309)

Programmed cell death protein 1 (PD-1), also known as CD279, is a cell surface receptor belonging to the immunoglobulin superfamily that is involved in regulation and attenuation of the adaptive immune response. It is a 288-amino acid type I transmembrane protein encoded by the PDCD1 gene in humans and is comprised of a 167-amino acid ectodomain consisting of an N-loop, IgV-like domain, and a stalk region, a transmembrane domain, and a cytoplasmic tail with two tyrosine-based signaling motifs. PD-1 is expressed in activated immune cells including CD4+ T cells, CD8+ T cells, natural killer T (NKT) cells, B cells, monocytes, and dendritic cells. Binding of PD-1 to either of its ligands, PD-L1 (Cay-28378) or PD-L2 (Cay-28379), suppresses T cell proliferation and cytokine production. PD-1 deficiency induces cardiomyopathy or lupus-like glomerulonephritis in BALB/c and C57Bl/6 mice, respectively. Increased levels of intratumoral PD-1+ immune cells are associated with increased tumor size, higher nuclear grade, and poor prognosis in patients with renal cell carcinoma. Formulations containing PD-1 blocking antibodies have been used in the treatment of various cancers. Cayman's PD-1/CD279 (N-Term) Rabbit Monoclonal Antibody (Clone RM309) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.Synonyms: CD279, PDCD1, Programmed Cell Death Protein 1. Immunogen: Peptide from the N-terminal region of human PD-1. Clone Designation: RM309. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody.. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: IHC, WB. Cross Reactivity: (+) PD-1.