Anti-PD-1/CD279

Anti-PD-1/CD279
Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-70311.60 60 µl - -

7 - 16 business days*

117.00€
 
Programmed cell death 1 (PD-1,also known as CD279) is an immunoinhibitory receptor that belongs... more
Product information "Anti-PD-1/CD279"
Programmed cell death 1 (PD-1,also known as CD279) is an immunoinhibitory receptor that belongs to the CD28/CTLA-4 subfamily of the Ig superfamily. It is a 288 amino acid (aa) type I transmembrane protein composed of one Ig superfamily domain,a stalk,a transmembrane domain,and an intracellular domain containing an immunoreceptor tyrosine-based inhibitory motif (ITIM) as well as an immunoreceptor tyrosine-based switch motif (ITSM) . PD-1 is expressed during thymic development and is induced in a variety of hematopoietic cells in the periphery by antigen receptor signaling and cytokines . Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation,cytokine production,and cytolytic function . It is critical for the regulation of T cell function during immunity and tolerance. Blockade of PD-1 can overcome immune resistance and also has been shown to have antitumor activity . The calculated molecular weight of PD-1 is 32 kDa. It has been reported that PD-1 is heavily Protein function: Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen- specific manner. Possible cell death inducer, in association with other factors. [The UniProt Consortium]
Keywords: Anti-PD1, Anti-CD279, Anti-PDCD1, Anti-hPD-1, Anti-Protein PD-1, Anti-Programmed cell death protein 1, PD-1/CD279 Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-70311

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse PD-1

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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