Anti-PCNA Recombinant Monoclonal

Item number Size Datasheet Manual SDS Delivery time Quantity Price
A700-075-T 10 µl (5+ tests) -

2 - 8 business days*

172.00€
A700-075 100 µl (50+ tests) -

2 - 8 business days*

655.00€
 
Protein function: Auxiliary protein of DNA polymerase delta and is involved in the control of... more
Product information "Anti-PCNA Recombinant Monoclonal"
Protein function: Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'- 5' exonuclease and 3'-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion (PubMed:24695737). [The UniProt Consortium]
Keywords: Anti-PCNA, Anti-Cyclin, Anti-Proliferating cell nuclear antigen
Supplier: Bethyl Laboratories
Supplier-Nr: A700-075

Properties

Application: WB, IHC, ICC, IHC-IF
Antibody Type: Monoclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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