Anti-PCNA, clone 1A1

Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-22001.20 20 µl -

7 - 16 business days*

72.00€
E-AB-22001.60 60 µl -

7 - 16 business days*

142.00€
E-AB-22001.120 120 µl -

7 - 16 business days*

238.00€
E-AB-22001.200 200 µl -

7 - 16 business days*

395.00€
 
This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of... more
Product information "Anti-PCNA, clone 1A1"
This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Protein function: Auxiliary protein of DNA polymerase delta and epsilon, is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand (PubMed:35585232). Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion (PubMed:24695737). [The UniProt Consortium]
Keywords: Anti-PCNA, Anti-Cyclin, Anti-Proliferating cell nuclear antigen, PCNA Monoclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-22001

Properties

Application: WB, IHC (paraffin), IF
Antibody Type: Monoclonal
Clone: 1A1
Conjugate: No
Host: Mouse
Species reactivity: human, mouse, rat
Immunogen: Synthetic Peptide
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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