Anti-Parkin (RING-type E3 ubiquitin-protein ligase)

Anti-Parkin (RING-type E3 ubiquitin-protein ligase)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
P3112-03G.40 40 µg - -

3 - 19 business days*

346.00€
 
Parkin, also known as PARKIN2, is a novel protein in Ubl conjugation pathway. Parkin functions... more
Product information "Anti-Parkin (RING-type E3 ubiquitin-protein ligase)"
Parkin, also known as PARKIN2, is a novel protein in Ubl conjugation pathway. Parkin functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include CCNE1, SYT11, GPR37, and STUB1, a 22 kD O-linked glycosylated isoform of SNCAIP and SEPT5. Parkin may play a more general role in the ubiquitin proteasomal pathway by participating in the removal and/or detoxification of abnormally folded or damaged protein. The protein may protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity. Defects in PARK2 are a cause of Parkinson disease (PD). Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 0.05-0.2ug/ml, Western Blot: 0.5-1ug/ml, Immunohistochemistry: 5-10ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute by adding sterile 40-50% glycerol, ddH2O. Reconstituted product is stable for 12 months at -20ºC. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: Anti-PRKN, EC=6.3.2.-, Anti-PARK2, Anti-Parkinson disease protein 2, Anti-E3 ubiquitin-protein ligase parkin, Anti-Parkinson juvenile disease protein 2
Supplier: United States Biological
Supplier-Nr: P3112-03G

Properties

Application: ELISA, IHC, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide within residues 300-350 of human parkin protein (Swiss Prot: O60260). (KLH coupled)
Purity: Purified by immunoaffinity chromatography.
Format: Affinity Purified

Handling & Safety

Storage: -20°C (-20°C Glycerol)
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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