Anti-PARK7 (CAP1, DJ1, DJ-1, DJ1 Protein, FLJ27376, Oncogene DJ1, Parkinson Disease (Autosomal Reces

Anti-PARK7 (CAP1, DJ1, DJ-1, DJ1 Protein, FLJ27376, Oncogene DJ1, Parkinson Disease (Autosomal Reces
Item number Size Datasheet Manual SDS Delivery time Quantity Price
P3110-99K.100 100 µl - -

3 - 19 business days*

498.00€
 
PARK7/DJ1 is a ubiquitously expressed protein involved in various cellular processes including... more
Product information "Anti-PARK7 (CAP1, DJ1, DJ-1, DJ1 Protein, FLJ27376, Oncogene DJ1, Parkinson Disease (Autosomal Reces"
PARK7/DJ1 is a ubiquitously expressed protein involved in various cellular processes including cell proliferation, RNA-binding, and oxidative stress. The protein has been found to colocalize within a subset of pathologic tau inclusions in a diverse group of neurodegenerative disorders known as tauopathies (Rizzu et al. 2004). Four chromosomal loci (PARK2, PARK6, PARK7, and PARK9) associated with autosomal recessive, early onset parkinsonism are known. Positional cloning within the refined PARK7 critical region recently identified mutations in the DJ-1 gene in PARK7-linked families. Defects in PARK7/DJ1 are the cause of autosomal recessive early-onset Parkinson's disease 7 (PARK7). Parkinson's disease (PD) is a complex, multifactorial disorder that typically manifests after the age of 50 years. The disease is characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. PARK7 is characterized by onset before 40 years and slow progression. It has also been suggested that PARK7/DJ1 is a mitogen dependent oncogene product involved in Ras related signal transduction pathways. Applications: Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence/Immunocytochemistry and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000, Immunohistochemistry: 1:1000, Immunohistochemistry (paraffin): 1:1000 Requires HIER using sodium citrate buffer pH6.0, Immunofluorescence (IC): 1:100-1:500, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: EC=3.4.-.-, Anti-Parkinson disease protein 7
Supplier: United States Biological
Supplier-Nr: P3110-99K

Properties

Application: ICC, IF, IHC, IP, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: A synthetic peptide mapping to the human PARK7 (DJ-1) protein, residues 167-189.
Purity: Purified
Format: Purified

Handling & Safety

Storage: -20°C (-20°C Glycerol)
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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