Anti-PAN3

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A304-914A-T	10 µl (10 µg)		-		2 - 8 business days*		164.00€
A304-914A	100 µl (100 µg)		-		2 - 8 business days*		588.00€

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Protein function: Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of... more

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Product information "Anti-PAN3"

Protein function: Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins. [The UniProt Consortium]

Keywords:	Anti-PAN deadenylation complex subunit 3, Anti-PAN2-PAN3 deadenylation complex subunit PAN3, Anti-PAB1P-dependent poly(A)-specific ribonuclease, Anti-Poly(A)-nuclease deadenylation complex subunit 3
Supplier:	Bethyl Laboratories
Supplier-Nr:	A304-914A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: gorilla, chimpanzee)
Immunogen:	synthetic peptide. The epitope recognized by A304-914A-T maps to a region between residue 175 to 225 of human PAB-dependent poly using the numbering given in entry Q58A45.3 (GeneID 255967).
Format:	Antigen Affinity Purified