Anti-p62/SQSTM1

Anti-p62/SQSTM1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay24693-500 500 µl -

6 - 10 business days*

535.00€
 
p62, also known as sequestosome-1 (SQSTM1), is a 62 kDa protein that acts as a signaling hub and... more
Product information "Anti-p62/SQSTM1"
p62, also known as sequestosome-1 (SQSTM1), is a 62 kDa protein that acts as a signaling hub and autophagy substrate and adaptor. It is a multi-domain protein that includes a Phox1 and Bem1p (PB1) domain, a zinc finger, a tumor necrosis factor receptor-associated factor 6 (TRAF6) binding domain, a ubiquitin-associated (UBA) domain, LC3- and Keap1-interacting regions, as well as two nuclear localization and one nuclear export sequence. p62/SQSTM1 is constitutively expressed and is primarily localized in the cytoplasm, however, it is also expressed in the nucleus, autophagosomes, lysosomes, and inclusion bodies containing polyubiquitinated protein aggregates. It is overexpressed in a variety of human cancer cells as well as in the chronic liver diseases alcoholic and non-alcoholic steatohepatitis (NASH). p62/SQSTM1 binds to ERK1, RIP1, TRAF6, Raptor, PKC, LC3, and Keap1 to activate mammalian target of rapamycin complex 1 (mTORC1), NF-kappaB, and nuclear factor erythroid 2-related factor 2 (NRF2) signaling in response to oxidative and endoplasmic reticulum (ER) stress. It functions as a cargo receptor in selective autophagy to shuttle aggregated and damaged proteins and organelles to autophagosomes for clearance. Mutations in the UBA domain of the SQSTM1 gene are associated with Paget's diseases. Cayman's p62/SQSTM1 Polyclonal Antibody can be used for WB and ELISA applications. The antibody recognizes p62/SQSTM1 at ~60 kDa from human samples.Synonyms: Sequestosome-1, Ubiquitin-binding Protein p62. Immunogen: A synthetic peptide from the C-terminal region of human p62. Formulation: (Request formulation change), 500 µl of Peptide affinity-purified IgG. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Rabbit. Applications: ELISA and WB. UniProt Accession #: Q13501.
Keywords: Anti-p60, Anti-p60, Anti-ORCA, Anti-EBIAP, Anti-EBIAP, Anti-SQSTM1, Anti-Sequestosome-1, Anti-Sequestosome-1, Anti-Ubiquitin-binding protein p62, Anti-Ubiquitin-binding protein p62, Anti-EBI3-associated protein of 60 kDa, Anti-EBI3-associated protein of 6
Supplier: Cayman Chemical
Supplier-Nr: 24693

Properties

Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: A synthetic peptide from the C-terminal region of human p62
Format: Solid

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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