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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V3807SAF-100UG | 100 µg | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
1 mg/ml in 1X PBS, BSA free, sodium azide free. The progression of cells through the cell cycle... more
Product information "Anti-p14ARF / CDKN2A, clone 4C6/4"
1 mg/ml in 1X PBS, BSA free, sodium azide free. The progression of cells through the cell cycle is regulated by a family of proteins designated cyclin-dependent kinases (Cdks). Sequential activation of individual members of this family and their consequent phosphorylation of critical substrates promotes orderly progression through the cell cycle. Multiple proteins are encoded by the tumor suppressor gene CDKN2A (MTS1/ p16INK4a) via translation of alternate reading frames, resulting in the production of the p19ARF protein in mice and the p14ARF protein in humans. p14ARF induces an increase in MDM2 and p21 levels and leads to cell cycle arrest in both G1 and G2/M. p14ARF is negatively regulated by p53 and is known to bind directly to MDM2. CDKN2A also encodes the mitotic protein p16, which binds to and inhibits the Cdk4/cyclin D complex. Protein function: Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. [The UniProt Consortium]
Keywords: | Anti-CDK4I, Anti-CDKN2, Anti-MTS-1, Anti-p16-INK4, Anti-p16INK4A, Anti-p16-INK4a, Anti-Multiple tumor suppressor 1, Anti-Cyclin-dependent kinase inhibitor 2A, Anti-Cyclin-dependent kinase 4 inhibitor A, p14ARF Antibody / CDKN2A |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V3807SAF |
Properties
Application: | IHC (paraffin), IF, FC, WB |
Antibody Type: | Monoclonal |
Clone: | 4C6/4 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human, rat |
Immunogen: | Full-length recombinant human protein used as the immunogen for the p14ARF antibody. |
Format: | Purified |
Database Information
KEGG ID : | K06621 | Matching products |
UniProt ID : | P42771 | Matching products |
Gene ID | GeneID 1029 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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