Anti-OPG

Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-F43211-0.08ML 80 µl - -

3 - 10 business days*

326.00€
NSJ-F43211-0.4ML 400 µl - -

3 - 10 business days*

702.00€
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. The protein encoded by this gene is a member of the... more
Product information "Anti-OPG"
In 1X PBS, pH 7.4, with 0.09% sodium azide. The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. Protein function: Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. [The UniProt Consortium]
Keywords: Anti-OCIF, Anti-TNFRSF11B, Anti-Osteoprotegerin, Anti-Osteoclastogenesis inhibitory factor, Anti-Tumor necrosis factor receptor superfamily member 11B, OPG Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: F43211

Properties

Application: WB, IF, IHC, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: A portion of amino acids 243-271 from the human protein was used as the immunogen for this OPG antibody.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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