Anti-NUMBL

Anti-NUMBL
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Item number Size Datasheet Manual SDS Delivery time Quantity Discount Price
G-CAB14088.100 100 µl -

9 - 20 business days

10 %
314.00€
282.60€
 
IHC 1:50 - 1:200. Protein function: Plays a role in the process of neurogenesis. Required... more
Product information "Anti-NUMBL"
IHC 1:50 - 1:200. Protein function: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF- kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. [The UniProt Consortium]
Keywords: Anti-NUMBL, Anti-Numb-R, Anti-Numb-like protein, Anti-Numb-related protein, NUMBL Polyclonal Antibody (CAB14088)
Supplier: Antibody Genie
Supplier-Nr: CAB14088

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 330-609 of human NUMBL (NP_004747.1).
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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