Anti-NUMBL, CT (NUMBL, Numb-like protein, Numb-related protein) (AP)

Anti-NUMBL, CT (NUMBL, Numb-like protein, Numb-related protein) (AP)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
039212-AP.200 200 µl - -

1 - 19 business days

696.00€
 
NUMBL plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to... more
Product information "Anti-NUMBL, CT (NUMBL, Numb-like protein, Numb-related protein) (AP)"
NUMBL plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. Applications: Suitable for use in Western Blot, Immunohistochemistry, ELISA, Recommended Dilution: ELISA: 1:1,000, Western Blot: 1:100-500, Immunohistochemistry: 1:10-50, Storage and Stability: Store product at 4°C. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap. , , Note: Applications are based on unconjugated antibody.
Supplier: United States Biological
Supplier-Nr: 039212-AP

Properties

Application: ELISA, IHC, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Format: Affinity Purified

Database Information

UniProt ID : Q9Y6R0 | Find alternatives

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: °C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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