Anti-NuMA, clone A73-B/D12

Anti-NuMA, clone A73-B/D12
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V2767-20UG 20 µg - -

3 - 10 business days*

332.00€
NSJ-V2767-100UG 100 µg - -

3 - 10 business days*

752.00€
 
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Recognizes a phosphorylated... more
Product information "Anti-NuMA, clone A73-B/D12"
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Recognizes a phosphorylated protein of 228kDa, identified as nuclear mitotic apparatus protein (NuMA). Its epitope is resistant to phosphatases. NuMA is intra-nuclear protein and present in nucleus during interphase. At the onset of mitosis, it redistributes from the nucleus to two centrosomal structures that later will become part of the mitotic spindle pole. After anaphase, the protein redistributes from the spindle polar region into reforming nucleus. NuMA is an essential protein during mitosis for the terminal phases of chromosome separation and/or nuclear reassembly. Recently a study shows that NuMA is cleaved to a 180 to 200kDa during apoptosis. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 has been detected in patients with acute promyelocytic leukemia. Protein function: Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles, functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in coordination of the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric cell divisions. [The UniProt Consortium]
Keywords: Anti-NMP-22, Anti-NuMA protein, Anti-SP-H antigen, Anti-Nuclear matrix protein-22, Anti-Nuclear mitotic apparatus protein 1, NuMA Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V2767

Properties

Application: WB, IF, IHC (paraffin)
Antibody Type: Monoclonal
Clone: A73-B/D12
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: Colon carcinoma 174T cells
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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