Anti-NPL4

Item number	Size	Manual	Delivery time	Price
A304-102A-T	20 µl (2 blots)	-	3 - 9 business days*	131.00€
A304-102A-M	100 µl (10 blots)	-	3 - 9 business days*	313.00€
A304-102A	100 µl (100 µg)	-	3 - 9 business days*	465.00€

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Protein function: The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated... more

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Product information "Anti-NPL4"

Protein function: The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729). [The UniProt Consortium]

Keywords:	Anti-NPLOC4, Anti-KIAA1499, Anti-Protein NPL4, Anti-Nuclear protein localization protein 4 homolog
Supplier:	Bethyl Laboratories
Supplier-Nr:	A304-102A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Reactivity:	Human, Mouse (Expected: Horse, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, White-tufted-ear Marmoset, Crab-eating Macaque, Thirteen-lined Ground Squirrel)
Immunogen:	synthetic peptide. The epitope recognized by A304-102A-T maps to a region between residue 75 to 125 of human Nuclear Protein Localization 4 Homolog using the numbering given in entry NP_060391.2 (GeneID 55666).
Format:	Antigen Affinity Purified