Anti-NOX4 (NADPH Oxidase 4, NOX-4, Renal NAD(P)H-Oxidase, RENOX, Kidney Superoxide-producing NADPH o

Anti-NOX4 (NADPH Oxidase 4, NOX-4, Renal NAD(P)H-Oxidase, RENOX, Kidney Superoxide-producing NADPH o
Item number Size Datasheet Manual SDS Delivery time Quantity Price
N5376-77.100 100 µl - -

3 - 19 business days*

546.00€
 
Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase,... more
Product information "Anti-NOX4 (NADPH Oxidase 4, NOX-4, Renal NAD(P)H-Oxidase, RENOX, Kidney Superoxide-producing NADPH o"
Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex. NOX4 has a role as a redox messenger in the activation of intracellular signaling pathways leading (or contributing) to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells. Data suggest that NOX4 provides a novel link between the insulin receptor and the generation of cellular reactive oxygen species that enhances insulin signal transduction. Cellular Localization: Endoplasmic reticulum, endoplasmic reticulum membrane, multi-pass membrane protein, cell membrane, nucleus (probable). , Applications: , Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Supplier: United States Biological
Supplier-Nr: N5376-77

Properties

Application: IHC, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: A synthetic peptide made to a region within residues 100-200 of the human NOX4 protein sequence. [Swiss-Prot# Q9NPH5]. Homology: 100% human, mouse, rat, cow, sheep, and monkey proteins.
Purity: Purified by peptide immunoaffinity chromatography.
Format: Affinity Purified

Database Information

Handling & Safety

Storage: +4°C (-20°C Glycerol)
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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