Anti-NLRP3

Anti-NLRP3
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-F51203-0.08ML 80 µl - -

3 - 10 business days*

326.00€
NSJ-F51203-0.4ML 400 µl - -

3 - 10 business days*

702.00€
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. NLRP3 is a pyrin-like protein containing a pyrin... more
Product information "Anti-NLRP3"
In 1X PBS, pH 7.4, with 0.09% sodium azide. NLRP3 is a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Protein function: As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitement of proCASP1 to the inflammasome promotes its activation and CASP1- catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP3 inflammasome is also required for HMGB1 secretion (PubMed:22801494). The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. Under resting conditions, NLRP3 is autoinhibited. NLRP3 activation stimuli include extracellular ATP, reactive oxygen species, K(+) efflux, crystals of monosodium urate or cholesterol, beta-amyloid fibers, environmental or industrial particles and nanoparticles, etc. However, it is unclear what constitutes the direct NLRP3 activator. Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth. During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription. Binds to the consensus DNA sequence 5'- GRRGGNRGAG-3'. May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF. [The UniProt Consortium]
Keywords: Anti-NLRP3, Anti-C1orf7, Anti-CLR1.1, Anti-Cryopyrin, Anti-Caterpiller protein 1.1, Anti-PYRIN-containing APAF1-like protein 1, Anti-Angiotensin/vasopressin receptor AII/AVP-like, Anti-NACHT, LRR and PYD domains-containing protein 3, NLRP3 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: F51203

Properties

Application: WB, IHC, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: A portion of amino acids 65-91 from the human protein was used as the immunogen for this NLRP3 antibody.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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