Anti-NKX3.1, clone NKX3.1/2836

Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V7977-20UG 20 µg - -

3 - 10 business days*

332.00€
NSJ-V7977-100UG 100 µg - -

3 - 10 business days*

752.00€
 
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. NKX3.1 is a prostate specific gene... more
Product information "Anti-NKX3.1, clone NKX3.1/2836"
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. NKX3.1 is a prostate specific gene encoding a transcription factor that plays an important role in normal prostate development and carcinogenesis. It is a prostatic tumor suppressor gene located on chromosome 8p21.2, which frequently undergoes a loss of heterozygosity. NKX3.1 expression is highly restricted in prostate epithelial cells and therefore can be used as a diagnostic biomarker for prostate cancer and other metastatic lesions of prostatic origin. Furthermore, NKX3.1 shows better sensitivity than Prostate Specific Antigen (PSA) for identifying metastatic prostatic adenocarcinoma. This suggests that immunohistochemical staining of NKX3.1, along with other prostate-restricted markers, may be valuable for the definitive determination of prostatic origin in poorly differentiated metastatic carcinomas. Protein function: Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. [The UniProt Consortium]
Keywords: Anti-NKX3.1, Anti-NKX3-1, Anti-Homeobox protein Nkx-3.1, Anti-Homeobox protein NK-3 homolog A, NKX3.1 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V7977

Properties

Application: ELISA, IHC (paraffin)
Antibody Type: Monoclonal
Clone: NKX3.1/2836
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: A recombinant human partial protein (amino acids 92-224)
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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