Anti-NKX2.2 (recombinant antibody), clone NX2/1422R

Anti-NKX2.2 (recombinant antibody), clone NX2/1422R
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V7271IHC-7ML 7 ml - -

3 - 10 business days*

752.00€
 
Prediluted in 1X PBS, 0.1 mg/ml BSA (US sourced), 0.05% sodium azide, *For IHC use only*.... more
Product information "Anti-NKX2.2 (recombinant antibody), clone NX2/1422R"
Prediluted in 1X PBS, 0.1 mg/ml BSA (US sourced), 0.05% sodium azide, *For IHC use only*. Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. Antibody to NKX2.2 detects a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors. Protein function: Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter. [The UniProt Consortium]
Keywords: Anti-NKX2-2, Anti-NKX2.2, Anti-Homeobox protein Nkx-2.2, Anti-Homeobox protein NK-2 homolog B, Recombinant NKX2.2 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V7271IHC

Properties

Application: IHC (paraffin)
Antibody Type: Monoclonal
Clone: NX2/1422R
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: A human partial recombinant protein was used as the immunogen for this recombinant NKX2.2 antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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