Anti-NKX2.1

Anti-NKX2.1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-F45942-0.08ML 80 µl - -

3 - 10 business days*

326.00€
NSJ-F45942-0.4ML 400 µl - -

3 - 10 business days*

702.00€
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. This gene encodes a protein initially identified as a... more
Product information "Anti-NKX2.1"
In 1X PBS, pH 7.4, with 0.09% sodium azide. This gene encodes a protein initially identified as a thyroid-specific transcription factor. NKX2.1/TTF1 binds to thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. Protein function: Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1. [The UniProt Consortium]
Keywords: Anti-T/EBP, Anti-NKX2A, Anti-TTF-1, Anti-Homeobox protein Nkx-2.1, Anti-Thyroid nuclear factor 1, Anti-Thyroid transcription factor 1, Anti-Homeobox protein NK-2 homolog A, Anti-Thyroid-specific enhancer-binding protein, NKX2.1 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: F45942

Properties

Application: WB, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: A portion of amino acids 2-1 from the human protein was used as the immunogen for this NKX2.1 antibody.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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