Anti-NELFE

Anti-NELFE
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*1 Offer expires 31/07/2021
Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-61462.60 60 µl - -

7 - 16 business days*

117.00€
E-AB-61462.120 120 µl - -

7 - 16 business days*

208.00€
E-AB-61462.200 200 µl - -

7 - 16 business days*

363.00€
 
The protein encoded by this gene is part of a complex termed negative elongation factor (NELF)... more
Product information "Anti-NELFE"
The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins, however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Protein function: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1. [The UniProt Consortium]
Keywords: Anti-RD, Anti-NELFE, Anti-NELF-E, Anti-RNA-binding protein RD, Anti-Negative elongation factor E, NELFE Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-61462

Properties

Application: WB, IF
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: Recombinant protein of human NELFE

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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