Anti-Nedd4

Item number Size Datasheet Manual SDS Delivery time Quantity Price
600-401-B05S 25 µl - -

1 - 9 business days

132.00€
600-401-B05 100 µg - -

1 - 9 business days

493.00€
 
Protein function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2... more
Product information "Anti-Nedd4"
Protein function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading to the degradation of VEGFR- 2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2. [The UniProt Consortium]
Keywords: Anti-NEDD-4, EC=6.3.2.-, Anti-E3 ubiquitin-protein ligase NEDD4, Anti-Cell proliferation-inducing gene 53 protein, Anti-Neural precursor cell expressed developmentally down-regulated protein 4
Supplier: Rockland Immunochemicals
Supplier-Nr: 600-401-B05S

Properties

Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Horse, Macaque
Immunogen: synthetic peptide corresponding to an internal portion of the Nedd4 protein
MW: 115 kD
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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