Anti-N-Cadherin / CDH2, clone CDH2/1573

Anti-N-Cadherin / CDH2, clone CDH2/1573
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3318SAF-100UG 100 µg - -

3 - 10 business days

541.00€
 
1 mg/ml in 1X PBS, BSA free, sodium azide free. Recognizes a protein of ~140kDa, identified as... more
Product information "Anti-N-Cadherin / CDH2, clone CDH2/1573"
1 mg/ml in 1X PBS, BSA free, sodium azide free. Recognizes a protein of ~140kDa, identified as N-Cadherin (NCAD), also known as Cadherin 2, CDH2 and CD325. Cadherin 2 is a 140 kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. Expression of Cadherin 2 has been reported on a variety of normal tissues including neuronal, endothelial and muscle cells, and a subpopulation of early hematopoietic progenitor cells. Results aid in the classification of malignant non-carcinomatous neoplasms including mesotheliomas, chordomas, synovial sarcomas, malignant melanomas, epithelioid sarcomas, epithelioid angiosarcomas, clear cell sarcomas as well as serous and endometrioid tumors of the ovary have been demonstrated to be Cadherin 2 positive, whereas mucinous tumors are negative. Other Cadherin 2-positive neoplasms include renal cell carcinomas and some variant breast tumors, including medullary breast carcinomas and sarcomatoid metaplastic breast carcinomas. Protein function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells, cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. [The UniProt Consortium]
Keywords: Anti-CDH2, Anti-CDHN, Anti-CD325, Anti-CDw325, Anti-Cadherin-2, Anti-N-cadherin, Anti-Neural cadherin, N-Cadherin Antibody / CDH2
Supplier: NSJ Bioreagents
Supplier-Nr: V3318SAF-100UG

Properties

Application: FC, WB, IF, IHC (paraffin)
Antibody Type: Monoclonal
Clone: CDH2/1573
Conjugate: No
Host: Mouse
Reactivity: Human, Mouse
Immunogen: A human partial recombinant protein corresponding to the intracellular portion of CDH2 was used as the immunogen for this Cadherin 2 antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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