Anti-Myeloperoxidase (MPO, pANCA, 84kD Myeloperoxidase, 89kD Myeloperoxidase, Myeloperoxidase Heavy

Anti-Myeloperoxidase (MPO, pANCA, 84kD Myeloperoxidase, 89kD Myeloperoxidase, Myeloperoxidase Heavy
Item number Size Datasheet Manual SDS Delivery time Quantity Price
M9760-10K.250 250 µg - -

3 - 19 business days

557.00€
 
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for... more
Product information "Anti-Myeloperoxidase (MPO, pANCA, 84kD Myeloperoxidase, 89kD Myeloperoxidase, Myeloperoxidase Heavy"
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. MPO is an important marker for myeloid cells, from the promyelocyte stage and to the mature forms. CATALYTIC ACTIVITY: Donor + H2O2 = oxidized donor + 2 H2O. CATALYTIC ACTIVITY: Cl- + H2O2 = HOCl + 2 H2O. COFACTOR: Binds 1 calcium ion per heterodimer. COFACTOR: Binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer. SUBUNIT: Tetramer of two light chains and two heavy chains. Cellular Localization: Lysosome. Alternative Products: 3 named isoforms produced by alternative splicing. DISEASE: Defects in MPO are the cause of myeloperoxidase deficiency (MPD). MPD is an autosomal recessive defect that results in disseminated candidiasis. Belongs to the peroxidase family. XPO subfamily. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Supplier: United States Biological
Supplier-Nr: M9760-10K

Properties

Application: IHC, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: Myeloperoxidase isolated from human polymorphonuclear leucocytes.
Purity: Serum
Format: Serum

Database Information

Handling & Safety

Storage: -20°C (-20°C Glycerol)
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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