Anti-MTMR15

Anti-MTMR15
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-660A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A302-660A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A302-660A 100 µl (20 µg) -

3 - 9 business days*

465.00€
 
Protein function: Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited... more
Product information "Anti-MTMR15"
Protein function: Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL- induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (PubMed:25430771). Also has endonuclease activity toward 5'-flaps (PubMed:20603015, PubMed:20603016, PubMed:24981866). [The UniProt Consortium]
Keywords: Anti-hFAN1, Anti-Fanconi-associated nuclease 1, Anti-Myotubularin-related protein 15, Anti-FANCD2/FANCI-associated nuclease 1
Supplier: Bethyl Laboratories
Supplier-Nr: A302-660A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Orangutan, Rhesus Monkey, Gorilla, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A302-660A-T maps to a region between residue 1 and 50 of human myotubularin related protein 15 using the numbering given in entry NP_055782.3 (GeneID 22909).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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