Anti-MSK2

Anti-MSK2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-746A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A302-746A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A302-746A 100 µl (20 µg) -

3 - 9 business days*

465.00€
 
Protein function: Serine/threonine-protein kinase that is required for the mitogen or... more
Product information "Anti-MSK2"
Protein function: Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide- stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. [The UniProt Consortium]
Keywords: Anti-MSK2, Anti-RSKB, Anti-RPS6KA4, EC=2.7.11.1, Anti-S6K-alpha-4, Anti-Ribosomal protein kinase B, Anti-Ribosomal protein S6 kinase alpha-4, Anti-90 kDa ribosomal protein S6 kinase 4, Anti-Nuclear mitogen- and stress-activated protein kinase 2
Supplier: Bethyl Laboratories
Supplier-Nr: A302-746A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse (Expected: White-tufted-ear Marmoset)
Immunogen: synthetic peptide. The epitope recognized by A302-746A-T maps to a region between residue 722 and 772 of human Mitogen- and Stress-activated Protein Kinase 2 using the numbering given in entry NP_003933.1 (GeneID 8986).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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