Anti-MSH6 (IHC)

Anti-MSH6 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00119-T 10 µl (5+ slides) -

3 - 9 business days

IHC-00119 100 µl (50+ slides) -

3 - 9 business days

Protein function: Component of the post-replicative DNA mismatch repair system (MMR).... more
Product information "Anti-MSH6 (IHC)"
Protein function: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. [The UniProt Consortium]
Keywords: Anti-GTBP, Anti-p160, Anti-GTMBP, Anti-hMSH6, Anti-MutS protein homolog 6, Anti-MutS-alpha 160 kDa subunit, Anti-G/T mismatch-binding protein, Anti-DNA mismatch repair protein Msh6
Supplier-Nr: IHC-00119-T


Application: IHC
Antibody Type: Polyclonal
Host: Goat
Reactivity: Human (Expected: Orangutan, Gorilla, Chimpanzee, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by IHC-00119 maps to a region between residues 350 and 400 of human MutS homolog 6 using the numbering given in entry NP_000170.1 (GeneID 2956).
Format: Antigen Affinity Purified

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