Anti-Mouse Monoclonal Antibody To N-Cadherin (Clone: 8C11)

Anti-Mouse Monoclonal Antibody To N-Cadherin (Clone: 8C11)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABE-10-7653-25 25 µg -

3 - 11 business days*

170.00€
 
N-cadherin(CD325) is a 140 kD protein belongs to a transmembrane molecules that mediate calcium... more
Product information "Anti-Mouse Monoclonal Antibody To N-Cadherin (Clone: 8C11)"
N-cadherin(CD325) is a 140 kD protein belongs to a transmembrane molecules that mediate calcium dependent intracellular adhesion. Its extracellular region consists of five EC domains and has one cytoplasmic domain. N-cadherin is involved in organogenesis and maintenance of organ architecture by contributing to the sorting of heterogeneous cell types and in the cell adhesion needed to form tissues. N-cadherin is expressed by stem cells, myeloblasts, endothelial cells, and fibroblasts, and also is expressed in neural and muscle tissues and some types of carcinoma cells. CD325 associates with the cytoskeleton trough catenin proteins. Protein function: Calcium-dependent cell adhesion protein, preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. [The UniProt Consortium]
Keywords: Anti-CDHN, Anti-CDH2, Anti-CD325, Anti-CDw325, Anti-N-cadherin, Anti-Cadherin-2, Anti-Neural cadherin, Mouse Monoclonal Antibody To N-Cadherin (Clone: 8C11)
Supplier: Abeomics
Supplier-Nr: 10-7653-25

Properties

Application: IHC, FC, WB
Antibody Type: Monoclonal
Clone: 8C11
Conjugate: No
Host: Mouse
Species reactivity: mouse, human
Immunogen: Recombinant human N-cadherin extracellular domain (exact sequence is proprietary)
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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