Anti-Mouse Monoclonal Antibody To N-Cadherin (Clone: 13A9)

Anti-Mouse Monoclonal Antibody To N-Cadherin (Clone: 13A9)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABE-36-2000-100 100 µg -

3 - 11 business days*

853.00€
 
Recognizes a protein of ~140kDa, identified as N-Cadherin (NCAD), also known as CD325. NCAD is a... more
Product information "Anti-Mouse Monoclonal Antibody To N-Cadherin (Clone: 13A9)"
Recognizes a protein of ~140kDa, identified as N-Cadherin (NCAD), also known as CD325. NCAD is a member of the Cadherin superfamily, and consists of five extracellular repeats, a transmembrane domain and a cytoplasmic domain. CD325 deficient mice die at day 10 of gestation and embryos display major heart defects and malformed neural tubes and somites. Consistent with this, CD325 has been implicated in several aspects of cardiac development including the precardiac mesoderm, establishment of left-right symmetry and cardiac looping morphogenesis. Furthermore, CD325 is normally involved in inducing cell cycle arrest and its expression is frequently deregulated in cancer cells. Studies have linked N-cadherin to cancer metastasis by showing the aggressive tumor cells had preferentially turned on N-cadherin as opposed to E- or P-cadherin. Protein function: Calcium-dependent cell adhesion protein, preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. [The UniProt Consortium]
Keywords: Anti-CDHN, Anti-CDH2, Anti-CD325, Anti-CDw325, Anti-N-cadherin, Anti-Cadherin-2, Anti-Neural cadherin, Mouse Monoclonal Antibody To N-Cadherin (Clone: 13A9)
Supplier: Abeomics
Supplier-Nr: 36-2000

Properties

Application: IHC, FC, WB
Antibody Type: Monoclonal
Clone: 13A9
Conjugate: No
Host: Mouse
Species reactivity: human, mouse
Immunogen: Recombinant human N-cadherin cytoplasmic domain (exact sequence is proprietary)
Format: Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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