Anti-METTL14

Anti-METTL14
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A305-847A-T 20 µl (2 blots) -

3 - 9 business days

125.00€
A305-847A-M 100 µl (10 blots) -

3 - 9 business days

290.00€
 
Protein function: The METTL3-METTL14 heterodimer forms a N6- methyltransferase complex that... more
Product information "Anti-METTL14"
Protein function: The METTL3-METTL14 heterodimer forms a N6- methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis (PubMed:24316715, PubMed:24407421, PubMed:25719671, PubMed:29348140, PubMed:27373337, PubMed:27281194). In the heterodimer formed with METTL3, METTL14 constitutes the RNA- binding scaffold that recognizes the substrate rather than the catalytic core (PubMed:27627798, PubMed:27373337, PubMed:27281194, PubMed:29348140). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing (PubMed:24316715, PubMed:24407421, PubMed:25719671). M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation. In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization. M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis. M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells. [The UniProt Consortium]
Keywords: Anti-hMETTL14, Anti-Methyltransferase-like protein 14, Anti-N6-adenosine-methyltransferase non-catalytic subunit
Supplier: Bethyl Laboratories
Supplier-Nr: A305-847A-T

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Mouse, X. Laevis, X. Tropicalis, Bovine, Orangutan)
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-METTL14"
Write a review
or to review a product.
Viewed