Item number Size Datasheet Manual SDS Delivery time Quantity Price
A303-580A-T 20 µl (2 blots) -

3 - 9 business days*

A303-580A-M 100 µl (10 blots) -

3 - 9 business days*

A303-580A 100 µl (100 µg) -

3 - 9 business days*

Protein function: Transcriptional repressor. Binds specifically to the DNA sequence... more
Product information "Anti-Mel-18"
Protein function: Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero- posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Is not functionally redundant with BMI1, unlike BMI1 does not stimulate the E3 ubiquitin-protein ligase activity in a reconstituted PRC1-like complex. [The UniProt Consortium]
Keywords: Anti-MEL18, Anti-PCGF2, Anti-Zinc finger protein 144, Anti-RING finger protein 110, Anti-DNA-binding protein Mel-18, Anti-Polycomb group RING finger protein 2
Supplier: Bethyl Laboratories
Supplier-Nr: A303-580A


Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, Crab-eating Macaque, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A303-580A-T maps to a region between residue 125 and 175 of human DNA-binding Protein Mel-18 using the numbering given in entry NP_009075.1 (GeneID 7703).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Our products are for laboratory research use only: Not for administration to humans!
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