Protein function: Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. [The UniProt Consortium]
Anti-MED1, Anti-MBD4, EC=3.2.2.-, Anti-Methyl-CpG-binding protein MBD4, Anti-Methyl-CpG-binding endonuclease 1, Anti-Methyl-CpG-binding domain protein 4, Anti-Mismatch-specific DNA N-glycosylase
Human (Expected: Orangutan, Gorilla, Chimpanzee, Northern White-cheeked Gibbon)
synthetic peptide. The epitope recognized by A301-635A-T maps to a region between residue 250 and 300 of human methyl-CpG binding domain protein 4 using the numbering given in entry NP_003916.1 (GeneID 8930).