Anti-MAVS (Clone: ABM2A90)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABE-10-4062-25 25 µg -

3 - 11 business days*

149.00€
 
Protein function: Required for innate immune defense against viruses. Acts downstream of DHX33,... more
Product information "Anti-MAVS (Clone: ABM2A90)"
Protein function: Required for innate immune defense against viruses. Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon- independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon- dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis. [The UniProt Consortium]
Keywords: Anti-MAVS, Anti-VISA, Anti-IPS1, Anti-IPS-1, Anti-Cardif, Anti-Virus-induced-signaling adapter, Anti-CARD adapter inducing interferon beta, Anti-Mitochondrial antiviral-signaling protein, Anti-Putative NF-kappa-B-activating protein 031N, Monoclonal antibo
Supplier: Abeomics
Supplier-Nr: 10-4062-25

Properties

Application: FC, WB
Antibody Type: Monoclonal
Clone: ABM2A90
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: A partial length recombinant protein (Amino acids 72-296) of human MAVS was used as immunogen for this antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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