Anti-MATN4 / Matrilin 4

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. MATN4 antibody detects Matrilin-4, a secreted extracellular matrix adapter protein that contributes to the structural organization of cartilage, tendon, and connective tissue matrices. The UniProt recommended name is Matrilin-4 (MATN4). This glycoprotein is a member of the matrilin family, which functions as extracellular linkers connecting collagen fibrils, proteoglycans, and other matrix molecules.Functionally, MATN4 antibody identifies a 602-amino-acid modular protein containing von Willebrand factor A (vWFA) domains and coiled-coil motifs. MATN4 interacts with matrix components such as aggrecan, COMP, and collagens II and IX, facilitating the formation of filamentous networks that provide tensile strength and elasticity to connective tissues. It plays a structural and regulatory role in cartilage organization and tissue resilience under mechanical load.The MATN4 gene is located on chromosome 20q13.12 and encodes a protein expressed primarily in skeletal tissues, including cartilage, intervertebral discs, and developing bone. Matrilin-4 functions as an adaptor molecule linking fibrillar collagens to proteoglycan aggregates, stabilizing the extracellular matrix architecture. During development, MATN4 expression is tightly regulated by transcription factors such as SOX9 and RUNX2 that control chondrogenesis and osteogenesis.In physiology, MATN4 supports cartilage integrity and joint function. Reduced expression or mutations in matrilin family proteins can impair cartilage matrix stability, predisposing to osteoarthritis or connective tissue degeneration. MATN4 also contributes to tissue repair by enhancing chondrocyte adhesion and matrix assembly following injury. In cancer biology, altered MATN4 expression has been reported in breast, gastric, and pancreatic cancers, where it may influence tumor cell adhesion and invasion through modulation of the extracellular matrix microenvironment.MATN4 antibody is widely used in extracellular matrix, musculoskeletal, and developmental biology research. It is suitable for immunohistochemistry, ELISA, and western blotting to detect Matrilin-4 expression and distribution. This antibody supports studies of cartilage formation, joint pathology, and matrix protein interactions. In biomaterials research, MATN4 serves as a reference marker for cartilage scaffold design and regenerative tissue engineering.Structurally, Matrilin-4 consists of vWFA domains that mediate protein-protein binding and a coiled-coil domain enabling tetramer formation. It is secreted via the classical ER-Golgi pathway and undergoes glycosylation for structural stability. NSJ Bioreagents provides MATN4 antibody reagents validated for use in extracellular matrix organization, skeletal development, and tissue engineering research.